Safeguarding Cell Therapy Cryopreservation: Primary Container Considerations

By Rui Li, Ph.D., and Krishnendu Khan, Ph.D., West Pharmaceutical Services, Inc.

This article explains the significance of selecting the appropriate container for cell therapy products during cryopreservation. The container material, form factor, and design play a crucial role in maintaining the viability and potency of the cells. Factors such as material composition, gas permeability, heat transfer properties, and inner surface characteristics should be considered when choosing a container. Insulative materials and form factors can help maintain stable temperatures for longer periods, while thinner, more conductive materials are more prone to transient warming events that can cause stress and damage to the cells.

Secondary packaging can be used to provide additional insulation and improve temperature stability. Container strength, flexibility, and form factor are also important for withstanding the expansion and contraction of contents during freezing and thawing.

Access the full article to better understand how to select cryo containers that meet the specific needs of your cryopreservation application and safeguard the cell therapy.