ARTICLES BY JOHN O'BRIEN
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![Digital tablet in pharmacy-GettyImages-1262631154]( "The Fifth Model: Where It Works, Where It Doesn't, And The Economics Behind It")
7/21/2026Where does the pharmacy card model fit? Explore its operational limits, cost advantages, regulatory considerations, and impact on comparator supply strategy.
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![Medical professional in pharmacy-GettyImages-2251394910]( "Beyond Push: A Pull-Based Model For Comparator Supply")
7/14/2026A prescription-based comparator supply model replaces bulk forecasting with on-demand dispensing, reducing lead times, waste, and inventory while expanding patient access.
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![production facilty, warehouse-GettyImages-2245890716]( "Zen And The Art Of Comparator Supply Maintenance")
5/26/2026Comparator sourcing may be the most expensive blind spot in clinical trials, driving massive waste, delays, shortages, and operational risk.
John O'Brien
John O’Brien is a clinical supply chain professional with experience managing comparator sourcing and distribution for global oncology clinical trials. His 2022 master’s capstone (CCP)project focused on re-engineering comparator supply through commercial pharmacy network integration and insurance cost-sharing, including collaboration with researchers at the Tufts Center for the Study of Drug Development, BeiGene (now BeOne Medicines), Myonex, TrialCard (now Veralis), and SupplyRx.